The power of biological replicates in statistical analysis
It is not uncommon that we see biological replicates are used in case-controlled studies. The reason is straightforward: there is no...
DNA Ghost:
This note based blog covers bioinformatics and cancer genomics
MCMC II: Applying MCMC in somatic variant calling
In PREVIOUS ARTICLE, we introduced theoretical basis of MCMC, its components and how it approximates the posterior distribution of...
MCMC: Monte Carlo sampling and Markov Chain
In PREVIOUS ARTICLE, we mentioned that Bayesian approach is being used for somatic variant detection. We will pick up this topic from...
An intuitive understanding of Bayesian statistics
In previous post, we mentioned that each locus across genome owns different noise rate due to variety of technical / biological factors....
Probability distribution in NGS data analysis
In previous POST, we discussed some basics of probability distribution and corresponding hypothesis testing. Here let's continue this...
Probability distribution and hypothesis testing
Bioinformatics is an interdisciplinary of biology (clinical medicine), computer science as well as statistics. To enable an in-depth...
Matrix factorization of high dimension data
In oncology research, it is a common goal to uncover specific molecular pattern of cancer. High-throughput sequencing has been become the...
Survival analysis and logistic regression
Survival analysis and logistic regression share certain similarities. The use of logistic regression for survival analysis, although not...
A general comparison: Generative vs Discriminative model
When comes to a general bioinformatics task, there are always a bunch of tools on which we have to evaluate based on their underlying...
Technical consideration with cell type decomposition
Ghost recently did some research on cell type decomposition technique, specifically TIL decomposition in tumor sample. TIMER and...