Ghost encountered dimension reduction problem while designing a model aiming to describe patient's immuno-oncology (IO) status. The model is supposed to incorporate well-known immune related factors listed in the figure below (for factor selection details, please read THIS and THIS) Most of these factors can be evaluated by either RNA-Seq or WES (except TIL localization and perhaps PD-L1 staining for CD8 activation). From modeling perspective, this generalization is a dimensi