This note based blog covers bioinformatics and cancer genomics
August 28, 2017
Ghost wanna share a good video illustrating how immunotherapy works.
Battle between tumor and immune system is a equilibrium phrase that can last years. This dynamic process consists of immunosurveillance and tumor progression.
During immunosurveillance, imm...
First, a figure shows why targeted therapy is, in certain circumstance, slightly better than chemo. Of course still less competitive than immunotherapy which will be discussed in the another topic.
In terms of toxicity:
Chemo targets all the fast growing cells and theref...
August 26, 2017
Figure below summarizes sources of some duplicate types:
Here Ghost gonna focus on the most common type: PCR duplicates and talk about how to treat them in several sequencing type data.
Where PCR duplicates come from and why do we care?
They are introduced when the...
August 25, 2017
Roughly, RNA-Seq may have the following bias sources:
PolyA selection (3’ bias) and ribosomal depletion
Normal cell contamination (when evaluating tumor)
Appears at firs...
An intuitive understanding of Bayesian statistics
May 25, 2020
Probability distribution in NGS data analysis
Probability distribution and hypothesis testing
February 7, 2020