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DNA Ghost:

This note based blog covers bioinformatics and cancer genomics 

May 14, 2018

Identifying somatic mutation has always been challenging.

Tumor heterogeneity

The major challenge of calling somatic mutation is heterogeneity of tumor tissue. Unlike germline variants usually having allele frequency (AF) around either 50% or 100% with a little deviation...

September 4, 2017

Figure below very well explains two important attributes of a variant: population frequency (to avoid confusion, we use "population frequency" instead of "allele frequency".) and effect size. Evolution dictates that variant's population frequency is generally inve...

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