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DNA Ghost:

This note based blog covers bioinformatics and cancer genomics 

December 27, 2018

Ghost recently did some research on cell type decomposition technique, specifically TIL decomposition in tumor sample. TIMER and CIBERSORT came across alone with their technical debates published on correspondence of Genome Biology. Li in Revisit linear regression-base...

December 3, 2018

Ghost came across this interesting figure on Cell Science and would like to take this opportunity to talk about tumor microenvironment. 

A route towards tumorigenesis

Tumor microenvironment is dynamic battlefield between tumor and immune system. This long-lasting ba...

November 30, 2018

Ghost encountered dimension reduction problem while designing a model aiming to describe patient's immuno-oncology (IO) status. The model is supposed to incorporate well-known immune related factors listed in the figure below (for factor selection details, please read...

October 26, 2018

First things first, the proposed classification are immune suppressing and immune escaping. Now let's go back for some specifics.

Immuno-oncology cycle

The whole immuno-oncology (IO) process can be briefly described as the following cycle. 

Tumor cells release neoantigen...

June 11, 2018

Immunotherapy has been the hot spot in cancer treatment in recent years. As a key component, neoantigen identification is usually done bioinformatically. If you are not familiar with concept of immunotherapy or neoantigen, please read THIS article first. Here Ghost wan...

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