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Technical consideration with cell type decomposition
Ghost recently did some research on cell type decomposition technique, specifically TIL decomposition in tumor sample. TIMER and CIBERSORT came across alone with their technical debates published on correspondence of Genome Biology. Li in Revisit linear regression-based deconvolution methods for tumor gene expression data asserts that, despite heavy regularization on linear model, CIBERCORT's inclusion of cell types with similar expression features causes multicolinearity and
