Ghost recently did some research on cell type decomposition technique, specifically TIL decomposition in tumor sample. TIMER and CIBERSORT came across alone with their technical debates published on correspondence of Genome Biology. Li in Revisit linear regression-based deconvolution methods for tumor gene expression data asserts that, despite heavy regularization on linear model, CIBERCORT's inclusion of cell types with similar expression features causes multicolinearity and

Ghost came across this interesting figure on Cell Science and would like to take this opportunity to talk about tumor microenvironment. A route towards tumorigenesis Tumor microenvironment is dynamic battlefield between tumor and immune system. This long-lasting battle, widely known as tumorigenesis, usually takes three main stages to achieve tumorigenesis. Immunosurveillance: The phase when immune system overwhelms tumor cells. multiple effector cells, such as T-cells, NK an