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MCMC: Monte Carlo sampling and Markov Chain
In PREVIOUS ARTICLE, we mentioned that Bayesian approach is being used for somatic variant detection. We will pick up this topic from here and spend two articles on building a site specific error model using MCMC for variant detection. Before walking into actual application, let's briefly talk about two major components of MCMC: Monte Carlo sampling and Markov Chain. Monte Carlo sampling Monte Carlo method is a sampling technique used for statistical estimation when direct ca