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The power of biological replicates in statistical analysis

MCMC II: Applying MCMC in somatic variant calling

MCMC: Monte Carlo sampling and Markov Chain

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Calling somatic variants without matched normal

Calling somatic variants without matched normal

Identifying somatic mutation has always been challenging. Tumor heterogeneity The major challenge of calling somatic mutation is...

Variant frequency, effect size and GWAS limitation

Variant frequency, effect size and GWAS limitation

Figure below very well explains two important attributes of a variant: population frequency (to avoid confusion, we use "population...

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